PrEP can be an effective part of a comprehensive HIV prevention package for HIV-negative individuals. San Francisco City Clinic (SFCC) patients who are at ongoing risk for HIV may benefit from taking PrEP. Taking PrEP requires regular follow-up with a healthcare provider. This protocol provides information on how SFCC initiates patients on PrEP and conducts follow-up. Also see Appendix A and Appendix B.